Non-steroidal anti-inflammatory drugs (nsaids) block the body’s inflammatory response. The body’s inflammatory response is generally a good thing; however, it does lead to an increase in pain for the cutaneous histiocytoma dog affected area. Inflammatory pain is often characterized by “start-up” pain – pain that occurs when you first get up in the cutaneous histiocytoma dog morning or after you have been sitting and then get cutaneous histiocytoma dog up. Taking non-steroidal anti-inflammatory drugs (nsaids) can lead to a noticeable short-term (6-8 hours) decrease in the pain associated with inflammation. However, nsaids will not address the underlying reason for the inflammatory cutaneous histiocytoma dog response (ex. Osteoarthritis, tendonitis, etc.) so they are effectively only masking the pain symptoms, not necessarily providing a permanent cure for the problem. Furthermore, there are many potential adverse reactions associated with NSAID use cutaneous histiocytoma dog some of which are very serious, even fatal. Stomach ulcers, bleeding ulcers, increased risk of heart attack, kidney failure, increased bleeding, and a risk of bones and tissues not healing have cutaneous histiocytoma dog all been associated with the use of nsaids. Patients with other risks factors for these conditions and older cutaneous histiocytoma dog patients should NOT take nsaids. Background information
Non-steroidal anti-inflammatory drugs (nsaids) are medications designed to decrease the body’s inflammatory response. NSAIDs can be very effective in treating the pain associated cutaneous histiocytoma dog with acute and chronic conditions which have an inflammatory component cutaneous histiocytoma dog (i.E most conditions that produce pain). The body’s inflammatory response is usually a good thing as it cutaneous histiocytoma dog facilitates the healing of injured soft tissues and bones. However, in conditions that produce a low level of chronic tissue cutaneous histiocytoma dog injury on a daily basis (ex. Osteoarthritis, tendonitis) or conditions that are associated with a large inflammatory response cutaneous histiocytoma dog (ex. Rheumatoid arthritis) this inflammatory response can lead to increased chronic pain. This inflammatory-type pain is often characterized by “start-up” pain. This is an increase in pain and stiffness that occurs cutaneous histiocytoma dog after the involved joint or tendon has been immobile for cutaneous histiocytoma dog a period of time. It explains why patients often have pain first thing in cutaneous histiocytoma dog the morning when they get out of bed, or after they get up from sitting for a period cutaneous histiocytoma dog of time. NSAIDs often can provide a substantial analgesic (pain relieving) effect by blocking the cylcooxygenase (COX) enzyme in the inflammatory pathway. This pathway produces prostaglandins which creates the inflammatory reaction. By blocking the production of prostaglandins the pain from the cutaneous histiocytoma dog inflammatory response is decreased. However, the underlying reason for the inflammatory response (ex. Osteoarthritis, tendonitis, etc.) is not addressed so nsaids will serve to mask the cutaneous histiocytoma dog symptoms, but often do not provide a permanent cure for the cutaneous histiocytoma dog problem. There seems to be relatively little difference in the clinical cutaneous histiocytoma dog efficacy between various nsaids, although some patient may respond better to some nsaids than cutaneous histiocytoma dog others. Indications for use
NSAIDs are typically used to treat both chronic and acute cutaneous histiocytoma dog pain and inflammation. NSAIDs are most effective when used for short term treatment cutaneous histiocytoma dog of acute injuries like minor strains and sprains. They can also be helpful for managing the symptoms associated cutaneous histiocytoma dog with chronic conditions with an inflammatory component, like arthritis. Most nsaids are cleared from the body through the kidneys cutaneous histiocytoma dog in about 6-8 hours. Side effects of anti-inflammatory drugs (nsaids)
The side effects associated with nsaids may limit their use cutaneous histiocytoma dog in certain conditions and in certain patients. Older patients, patients with a history of stomach problems or ulcers, and patients with kidney problems often need to avoid taking cutaneous histiocytoma dog nsaids due to potentially serious side effects. Conditions that require bone healing (ex. Fractures) or are associated with increase bleeding (ex. Many acute sprains and strains) may need to limit or avoid using nsaids as they cutaneous histiocytoma dog may have an adverse effect on bone healing (an inflammatory process) and will tend to increase bleeding. Specific side effects include:
• gastrointestinal (GI) bleeding: nsaids can lead to a bleeding stomach ulcer (the ulcer itself is actually in the duodenum, just past the stomach). This occurs because the nsaids block the production of prostaglandins cutaneous histiocytoma dog which normally facilitate the secretion of a protective lining (mucosa) in the stomach. Without this lining, the stomach acid is more likely to erode through the cutaneous histiocytoma dog tissue and produce bleeding. This bleeding can be sudden and potentially fatal, particularly in older individuals who may not be able to cutaneous histiocytoma dog tolerate a large blood loss. For this reason, nsaids should be used with great caution, particularly in older patients:
• I ncreased risk of heart attack (myocardial infarction): recent studies have suggested that use of nsaids in high cutaneous histiocytoma dog dosages and COX-2 antagonist (nsaids that only block the cyclooxygenase-2 enzyme) likely increase the risk of a heart attack by up cutaneous histiocytoma dog to 80%. Therefore patients with a previous heart attack, congestive heart failure, or significant risk factors for a heart attack (ex. Positive family history) should avoid the use of nsaids.
• increased bleeding: nsaids will tend to increase bleeding by indirectly inhibiting platelet cutaneous histiocytoma dog function (platelets help form blood clots) which thereby increases the risk of bleeding. The tendency to increase bleeding make nsaids less than ideal cutaneous histiocytoma dog for treating many acute injuries because of the potential to cutaneous histiocytoma dog cause more bleeding and therefore, more swelling and pain. Patients that are undergoing surgery should stop their NSAID use cutaneous histiocytoma dog about 10 days prior to surgery in order not to cutaneous histiocytoma dog increase the risk of bleeding associated with the surgery.
• kidney problems: nsaids can lead to significant kidney problems even producing complete cutaneous histiocytoma dog kidney failure. This is due to their effect of decreasing blood flow cutaneous histiocytoma dog to the kidneys (the effect of blocking the prostaglandin production). Kidney problems tend to occur more in patients with existing cutaneous histiocytoma dog kidney problems or in patients who are taking high doses cutaneous histiocytoma dog of nsaids over a longer period of time.
• bone healing problems: nsaids can be very helpful at relieving pain associated with cutaneous histiocytoma dog bone injuries such as fractures, or procedures that involve cutting or fusing bones. However, as bone healing is fundamentally an inflammatory process by inhibiting cutaneous histiocytoma dog this process there may be an increased risk of the cutaneous histiocytoma dog fracture or bone not healing leading to a non-union. To date, this limited bone healing response has been demonstrated in laboratory cutaneous histiocytoma dog animals only, and has not been confirmed in humans.
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