Hybrid vigor – the cavador angiomatoid malignant fibrous histiocytoma

The reason we have all the dog breeds that we angiomatoid malignant fibrous histiocytoma have today are due to selective breeding, line-breeding, and in-breeding, which has caused there to be distinctive traits that separate angiomatoid malignant fibrous histiocytoma that breed from all others.The problem with this is that it has also caused angiomatoid malignant fibrous histiocytoma many of the canine diseases that we have today.This is not to say that these breeding tools are angiomatoid malignant fibrous histiocytoma all bad, because that wold be untrue. Without these tools dogs would would not have been able angiomatoid malignant fibrous histiocytoma to be breed to serve the purpose that they were angiomatoid malignant fibrous histiocytoma bred for. Whether that be hunting, search and rescue, law enforcement, pest control, companionship, etc.

From this list we can see that are some genetic angiomatoid malignant fibrous histiocytoma diseases that both labradors and cavaliers are both predisposed to. For this reason all breeding pairs should be tested for angiomatoid malignant fibrous histiocytoma hip dyplasia and have eye clearance. It would also be suggested that labs are tested for angiomatoid malignant fibrous histiocytoma elbow dysplasia and cavaliers should have heart and patella testing. This is the same testing that purbreeds should undergo.

Now, this is the part where out-crossing becomes very helpful. Recessive gene diseases. All mammals have two of every gene. One from their mother and one from their father. A recessive gene trait is one that is only expressed angiomatoid malignant fibrous histiocytoma when an individual has two copies of that gene. If an individual has only one copy of the gene angiomatoid malignant fibrous histiocytoma they are considered a “carrier.” there are many recessive gene diseases in different dog breeds. One would think that it would be easy to get angiomatoid malignant fibrous histiocytoma rid of these, but in many cases there is not a single individual angiomatoid malignant fibrous histiocytoma of the breed that doesn’t have 2 copies of diseased gene. This is when out-crossing can be very helpful. By crossing one breed that only carries 2 recessive diseased angiomatoid malignant fibrous histiocytoma gene with a breed that doesn’t have the diseased gene guarantees that that offspring will angiomatoid malignant fibrous histiocytoma be free of that diseased trait.

Heart mitral valve disease (MVD) is the leading cause of death of cavalier king charles angiomatoid malignant fibrous histiocytoma spaniels throughout the world. MVD is a polygenetic disease (disease influence by several genes, not just one) which afflicts over half of all cavaliers by age 5 angiomatoid malignant fibrous histiocytoma years and nearly all cavaliers by age 10 years, should they survive that long. The prevalence of MVD in cavaliers is about 20 times angiomatoid malignant fibrous histiocytoma that of other breeds, and in cavaliers, the onset of the disease typically is much earlier in angiomatoid malignant fibrous histiocytoma the life of the dog. Labs do not carry the any genetic risk factors for angiomatoid malignant fibrous histiocytoma MVD so being that the disease is polygenic and labs angiomatoid malignant fibrous histiocytoma carry not genetic risk factors the likelihood of a early angiomatoid malignant fibrous histiocytoma onset MVD is a cavador is virtually eliminated.

Syringomyelia (SM) is an extremely serious condition in which fluid-filled cavities develop within the spinal cord near the brain. It is also known as “neck scratcher’s disease”, because one of its common signs is scratching in the angiomatoid malignant fibrous histiocytoma air near the neck. The back half of the cavalier king charles spaniel’s skull typically may be too small to accommodate all angiomatoid malignant fibrous histiocytoma of the brain’s cerebellum, which may also be too large, and so it squeezes through the foramen magnum – the hole at the back of the skull – partially blocking the flow of cerebrospinal fluid (CSF) down the spinal cord. The variable pressure created by the abnormal flow of CSF angiomatoid malignant fibrous histiocytoma is believed to create the SM cavities – called syrinx – in the spinal cord.

In general, most small breeds have the possibility of developing SM. Researchers think it is linked to breeding smaller dogs. Something happens as the head becomes smaller and neck shorter angiomatoid malignant fibrous histiocytoma and muzzle foreshortened that seems to trigger a mismatch in angiomatoid malignant fibrous histiocytoma development between skull and brain size. That is the best theoretical picture at the moment, based on clinical observation, genetic work, MRI and autopsy studies and some foetal studies.

Brachycephalic airway obstruction syndrome (BAOS), is an inherited condition in the cavalier king charles spaniel. The breed is predisposed to it, due to the comparatively short length of the cavalier’s head and a compressed upper jaw.The symptoms may vary and range in severity, depending upon which abnormality is causing them, but they typically include labored and constant open mouthed breathing, noisy breathing, snuffling, snorting, excessive snoring, gagging, retching, exercise and/or heat intolerance, general lack of energy, pale or bluish tongue and gums due to a lack angiomatoid malignant fibrous histiocytoma of oxygen. All cavadors will have longer muzzles than cavaliers and therefore angiomatoid malignant fibrous histiocytoma will have less problems associated with this.

Lab and cavaliers are predisposed to different eye diseases. A cross between the two provides a larger genepool to angiomatoid malignant fibrous histiocytoma help eleviate some of these problems. Most of the eye problems in cavaliers are thought to angiomatoid malignant fibrous histiocytoma be attributed to the brachycephalic shape of their heads. Labs do not have the same type of skull structure angiomatoid malignant fibrous histiocytoma so this reduces the risk of eye problems. That being said, dam and sire still should be tested and registered with angiomatoid malignant fibrous histiocytoma CERF.

A syndrome of exercise intolerance and collapse (EIC) is being observed with increasing frequency in young adult labrador angiomatoid malignant fibrous histiocytoma retrievers.Affected dogs can tolerate mild to moderate exercise but 5 angiomatoid malignant fibrous histiocytoma to 15 minutes of strenuous exercise induces weakness and then angiomatoid malignant fibrous histiocytoma collapse. EIC like CNM is also a recessive gene disease so angiomatoid malignant fibrous histiocytoma it would be impossible for a cavador to get EIC.

Labs are predisposed to many cancers and tumors including mast angiomatoid malignant fibrous histiocytoma cell tumor, cutaneous histiocytoma, sq. Cell carcinoma, nasal cavity tumors, insulinoma, lymphosarcoma, limbal melanoma, oral fibrosarcoma, thymoma. Some of these are less life threatening than others but angiomatoid malignant fibrous histiocytoma all reduce the quality of life of pets. Cavaliers are one of the few breeds that are not angiomatoid malignant fibrous histiocytoma predisposed to any particular cancers or tumors, so cavadors should have a reduced risk of tumors and angiomatoid malignant fibrous histiocytoma cancers.

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