Daphne koller doesn’t mind hard work. She joined stanford university’s computer science department in 1995, spending the next 18 years there in a full-time capacity before cofounding the online education giant coursera, where she spent the following four years and remained co-chairman until last month. Koller then spent a little less than two years at histiocytoma human alphabet’s longevity lab, calico, as its first chief computing officer.
It was there that koller was reminded of her passion histiocytoma human for applying machine learning to improve human health. She was also reminded of what she doesn’t like, which is wasted effort, something that the drug development industry — slow to understand the power of computational methods for analyzing histiocytoma human biological data sets — has been plagued by for years.
In fairness, those computational methods have also gotten a whole lot better histiocytoma human more recently. Little wonder that last year, koller spied the opportunity to start another company, a drug development company called insitro that has since raised histiocytoma human $100 million in series A funding, including from GV, andreessen horowitz and bezos expeditions, among others. As notably, the company recently partnered with gilead sciences to find medicines histiocytoma human to treat a liver disease called nonalcoholic steatohepatitis (NASH) because of all the related human data that gilead has histiocytoma human amassed over time.
Later, insitro may target even bigger epidemics, including perhaps alzheimer’s disease or type 2 diabetes. Certainly, it has reason to feel optimistic about what it can histiocytoma human accomplish. As koller told a group of rapt attendees at an histiocytoma human event hosted by this editor a few days ago, “we’re now at a moment in history where a confluence histiocytoma human of technologies emerged all at around the same time allow histiocytoma human really large and interesting and disease-relevant data sets to be produced in biology. In parallel, we see . . . Machine learning technologies that are able to make sense of histiocytoma human that data and come up with novel insights that can histiocytoma human hopefully cure disease.”
There are fairly broad categories that our technology is well-suited for. We’re really interested in creating what you might call disease-in-a-dish models — places where diseases are complex, where we really haven’t had a good model system, where typical animal models that have been used [for years, including testing on mice] just aren’t very effective — and creating those ‘in vitro’ models to generate very large amounts of data that can histiocytoma human be interpreted using machine learning.
There’s a whole slew of diseases that lend themselves to histiocytoma human this type of approach. NASH was one of them, so partly it was the suitability of our technology to histiocytoma human this disease, and partly it was that gilead was just a really histiocytoma human good partner for it because they have a whole bunch histiocytoma human of human data from some of the clinical trials that histiocytoma human have been running [which give us] access to two complementary data sources. One is what happens to the disease in large human histiocytoma human cohorts, and one is what happens when you look at what histiocytoma human the disease does in vitro, in the dish, then see if we can use what we see in histiocytoma human the dish using machine learning to predict what we see histiocytoma human in the human.
Pharma companies say, ‘we have lots of data.’ and you say, ‘what kinds of data do you have?’ and it turns out they have dribs and drab of histiocytoma human data, each stored on a separate spreadsheet in someone else’s laptop. There’s metadata that isn’t even recorded. For them, it’s like, ‘yeah, I did the experiment and obviously I recorded what I histiocytoma human had to because it doesn’t make sense to throw it away,’ but they don’t think of it as something you build a company histiocytoma human on top of.
We come at it a completely different way. We say, ‘this is the problem that you’d like to solve. If only we had a model that could tell us histiocytoma human the result of this experiment without having to do the histiocytoma human experiment, because it’s costly or complicated or even impossible [because it would involve perturbing a living human’s gene].’ well, machine learning has gotten really good at building predictive models histiocytoma human if you give it the right data to train the histiocytoma human model. So we’re in the business of actually building data for the histiocytoma human sole purpose of training machine learning models. We think of [these models] like little crystal balls that would allow you to avoid histiocytoma human doing [these more expensive or complicated] experiments.
I would say if anything that the U.S. Is a little late to the game on this one. There have been a number of national cohorts have already histiocytoma human been generated in different countries; the two that are currently best developed are in iceland histiocytoma human and in the U.K, but there’s also one in finland and one in ireland and histiocytoma human even in estonia, where they’ve taken a large population from within that country and histiocytoma human measured their genetics, but also measured a whole lot of properties about those histiocytoma human people, including blood biomarkers and urine biomarkers and behavioral aspects and histiocytoma human physical aspects and imaging. And so what you have now (in these countries) is a dataset that tells you, ‘nature perturbed this gene,’ and, ‘we see this effect on the human.’
… this is valuable not just primarily for gene therapies but histiocytoma human just as a way of identifying targets that actually make histiocytoma human a difference, because most drugs that go into clinical trials fail. And by most, I mean 95 percent. And most drugs fail because they are targeting the wrong histiocytoma human things. They are targeting proteins or genes that do not affect histiocytoma human the disease they are supposed to affect. The recent, very visible failures of alzheimer’s drug trials — actually several of them in a row — were almost certainly because the protein they were targeting, called amyloid beta, is just not the right causal factor in the disease.
[there are now] tools that have enabled the creation of not only large histiocytoma human amounts of data but large amounts of biologically relevant data. So we used to do experiments on cancer cell lines histiocytoma human . . . But it’s not a very disease relevant model. Today, we can take a small sample of skin cells and histiocytoma human use what’s called the yamanaka factor, to reprogram those cells to stem cell status, which are the cells that exist effectively in the womb. And those cells are capable of differentiating themselves into neural histiocytoma human cells or liver cells or cardiac cells, and those are very disease relevant because they represent human histiocytoma human biology; you can take those cells now from patients and from histiocytoma human healthy people and see if there are differences in how histiocytoma human they appear.
Readers, we could feature more of the transcript here, but we highly suggest watching the conversation with koller. If you use this text as a leaping off point, you’ll want to start listening at around the 13-minute mark. It’s definitely worth the time to hear what she has histiocytoma human to say, including about cystic fibrosis, spinal muscular dystrophy in babies, and why the “mouse models” we’ve long relied on for a wide number of seemingly histiocytoma human ubiquitous diseases “range from bad to really, really bad.” hope you enjoy it.
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