Benign fibrous histiocytoma of the bladder dog tumor histiocytoma de padua m, subramanium n – indian j urol

Mesenchymal tumors of the bladder are rare with leiomyoma accounting dog tumor histiocytoma for most of these. We present a rare case of a bladder benign fibrous dog tumor histiocytoma histiocytoma in a 52-year-old male. He presented with history of straining during micturition since two dog tumor histiocytoma years. The magnetic resonance imaging revealed a large intravesical mass. The mass was excised. It weighed 600g, with a maximum dimension of 13cm. Histology was that of a benign fibrous histiocytoma. To our knowledge, only two cases of this tumor have been reported in dog tumor histiocytoma the bladder so far. The clinical and pathological features are discussed.

Mesenchymal tumors of the bladder are rare with leiomyomas accounting dog tumor histiocytoma for most of the cases. [1] Fibrous histiocytoma is a benign tumor usually occurring in the dog tumor histiocytoma dermis and superficial subcutis. It is also uncommonly found in deep soft tissue and dog tumor histiocytoma sporadically in parenchymal organs. Only two cases of this tumor in the bladder have dog tumor histiocytoma been so far reported in the literature. [2], [3] We present the third case.

A 52-year-old male presented with complaints of straining during micturition for dog tumor histiocytoma two years, with poor stream of urine and burning micturition on and dog tumor histiocytoma off. There was no history of hematuria, pyuria or retention of urine. Systemic systems were not present. On examination, suprapubic lump was palpable, more on the right side. On cystoscopy, a large solid tumor arising from just above the bladder dog tumor histiocytoma neck along the right lateral wall, going anteriorly was seen. The magnetic resonance imaging (MRI) revealed a large encapsulated intravesical mass [Figure – 1]. There was no obvious extravesical extension. The radiological features were suggestive of a benign etiology, which could represent a mesenchymal tumor. Needle biopsy was performed followed by excision of the tumor. During surgery, an infraumbilical midline incision was taken, with an extraperitoneal approach. The tumor was palpated and bladder opened just lateral to dog tumor histiocytoma the tumor on the anterior surface. Mucosa over the tumor was incised and a plane was dog tumor histiocytoma developed. The tumor was freed from all mucosal attachments and enucleated. Pedicle of the tumor was transfixed and tumor was delivered.

Histology of the biopsy revealed a neoplasm composed of neoplastic dog tumor histiocytoma cells with uniform oval to spindled nuclei arranged in a dog tumor histiocytoma striking storiform pattern [Figure – 2]. There was no evidence of necrosis, mitotic activity or nuclear pleomorphism. Immunohistochemical stain with vimentin was strongly positive. Cytokeratin, smooth muscle actin, S-100 and desmin was negative. A diagnosis of a mesenchymal tumor, possibly benign was offered at this stage, since th amount of tissue studied was small. Subsequently, the excised specimen was received. Grossly, the tumor measured 13 x 10 x 9 cm and dog tumor histiocytoma weighed 600g [Figure – 3]. It was well circumscribed with a smooth surface. Cut surface showed a firm, nodular, yellowish white appearance. Histology revealed features as seen in the needle biopsy specimen. There was no evidence of nuclear atypia or mitotic activity dog tumor histiocytoma in multiple sections studied [Figure – 4]. The final diagnosis was benign fibrous histiocytoma.

Mesenchymal tumors of the bladder are rare with leiomyomas accounting dog tumor histiocytoma for most of the cases. [1] Other benign mesenchymal tumors of the bladder include hemangioma, lymphangioma, neurofibroma, neurilemmoma, granular cell tumor, benign fibrous histiocytoma and lipoma. [1] In tumors of fibrohistiocytic origin of the bladder, malignant fibrous histiocytoma has been reported more often than benign dog tumor histiocytoma fibrous histiocytoma. [4], [5], [6], [7], [8], [9] Only two cases of benign fibrous histiocytoma of the bladder dog tumor histiocytoma have been reported so far. [2], [3] The unusual feature in our case is its large size dog tumor histiocytoma (13 cm). Fibrous histiocytoma is a benign tumor usually occurring in the dog tumor histiocytoma dermis and superficial subcutis. It is also uncommonly found in deep soft tissue and dog tumor histiocytoma sporadically in parenchymal organs. These tumors are clinically benign and complete excision is usually dog tumor histiocytoma curative. While degerative atypia, necrosis, some level of mitotic activity and increased cellularity may be dog tumor histiocytoma seen as an isolated finding, increased mitotic activity with nuclear atypia should raise concerns about dog tumor histiocytoma malignancy. [10] There was no evidence of nuclear atypia, necrosis or mitotic activity in our case. Complete surgical excision was achieved in our patient. There is no evidence of recurrence after 10 months of dog tumor histiocytoma follow-up. The most controversial aspect of this tumor is its histogenesis. It has been variably interpreted as a histiocytic and fibroblastic dog tumor histiocytoma tumor. The presence of lysozymes and proteolytic enzymes has been interpreted dog tumor histiocytoma as evidence favoring a histiocytic origin. [11] The predominant fibroblastic appearance of the cells ultrastructurally and lack dog tumor histiocytoma of histiocytic markers have been used in support of a dog tumor histiocytoma fibroblastic origin. [12] Immunohistochemistry helps in differentiating from other tumors like leiomyoma, neurofibroma, schwannoma etc.

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