Autologous transplants are used to treat a number of different histiocytoma dog lip blood cancers. Autologous transplants allow the use of high-dose chemotherapy, which provides some patients with a better chance of cure histiocytoma dog lip or long-term control of their disease. Most people have a single autologous transplant. Others, particularly those with myeloma or some solid tumours, may have two or more sequential (one after the other) transplants, over a period of a few months.
Stem cells are usually collected when the patient’s disease is in remission or their disease is in histiocytoma dog lip a more stable state. In autologous stem cell transplantation, stem cells are collected (or “harvested”) from either the bone marrow, bloodstream (called a peripheral blood stem cell harvest), or sometimes a combination of both. It is more common these days to collect bone marrow histiocytoma dog lip stem cells from the bloodstream. Stem cells normally live in the bone marrow, but they can be encouraged to move out of the histiocytoma dog lip bone marrow and into the bloodstream. This process is called stem cell mobilisation and usually involves histiocytoma dog lip the use of chemotherapy in combination with colony stimulating growth histiocytoma dog lip factor injections – usually G-CSF. G-CSF promotes the production of stem cells in the bone histiocytoma dog lip marrow which then leak out into your normal blood circulation histiocytoma dog lip in your veins. Growth factor injections are usually given for several days, usually starting 24 hours after the completion of your chemotherapy.
Regular blood tests will be taken over the following week histiocytoma dog lip to identify the best day to start collecting your stem histiocytoma dog lip cells. It is important to keep taking your injections of growth histiocytoma dog lip factors at the same time every day until you are histiocytoma dog lip told to stop. Stem cells are collected from your bloodstream by passing all histiocytoma dog lip your blood through a special machine called a cell separator histiocytoma dog lip (or apheresis machine). The apheresis machine draws blood from the body, spins the blood very quickly, collects the part that contains the blood stem cells, and returns the rest of the blood back to the histiocytoma dog lip body. This is a continuous process. Conditioning therapy
In the week leading up to your transplant you will histiocytoma dog lip be given a few days of very high-dose chemotherapy, and sometimes radiotherapy, to destroy your underlying disease. This is called conditioning therapy. Conditioning therapy is used to help destroy any leftover cancer histiocytoma dog lip cells in your body and to make or create a histiocytoma dog lip space in your bone marrow for the new stem cells histiocytoma dog lip to grow. After you have finished this treatment, your stem cells are thawed and reinfused through a vein histiocytoma dog lip into your bloodstream. This is similar to a blood transfusion. From here the stem cells make their way to your histiocytoma dog lip bone marrow where they become re-established and start making new blood cells.
In the week following the transplant, your blood counts drop dramatically. This is to be expected. During this time you will be more at risk of histiocytoma dog lip infections (due to the lack of infection-fighting white blood cells) and bleeding (due to a lack of platelets). Antibiotics and other drugs are commonly prescribed to help prevent histiocytoma dog lip or treat infections during this time, and you are likely to need platelet transfusions to reduce histiocytoma dog lip your risk of bleeding.
Red blood cell transfusions are given when your haemoglobin levels histiocytoma dog lip are too low. During this time you are likely to be experiencing some histiocytoma dog lip of the common side effects of chemotherapy and radiotherapy which histiocytoma dog lip may include nausea, vomiting, mucositis (sore mouth) and bowel problems (diarrhoea). For more information on side effects of treatment please refer histiocytoma dog lip to our website’s section on your specific disease. Leaving hospital after a transplant
Despite this, many people experience a relapse of their original disease at histiocytoma dog lip some stage following an autologous transplant. If your disease relapses there are often ways of getting histiocytoma dog lip it back under control. These may include more chemotherapy and/or another transplant, or a drug to stimulate your immune system to fight histiocytoma dog lip the disease. Your doctor will advise you on your chances of relapse histiocytoma dog lip following an autologous transplant. Further information
Developed by the Leukaemia Foundation in consultation with people living histiocytoma dog lip with a blood cancer, Leukaemia Foundation support staff, haematology nursing staff and/or Australian clinical haematologists. This content is provided for information purposes only and we histiocytoma dog lip urge you to always seek advice from a registered health histiocytoma dog lip care professional for diagnosis, treatment and answers to your medical questions, including the suitability of a particular therapy, service, product or treatment in your circumstances. The Leukaemia Foundation shall not bear any liability for any histiocytoma dog lip person relying on the materials contained on this website. Share this page
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